Valerian (Valeriana officinalis)
Overview
Valerian (Valeriana officinalis) is an upright, clump-forming perennial reaching about 4 ft (1.2 m), with divided, pinnate leaves and pinkish-white clusters of small flowers. Known for its pungent (often unpleasant) smell, valerian is one of the most popular sedative and relaxant herbs in Western herbal medicine, helping to calm sympathetic overactivity, ease anxiety, and aid restful sleep.
Traditional uses & properties
Nervine & Sedative: Eases stress, mild pain, muscle tension, tremors, or “sympathetic excess”; promotes sleep, especially in insomnia due to nervous excitability. Antispasmodic & Analgesic: Alleviates tense or cramping conditions (e.g., menstrual cramps, neck/shoulder stiffness, irritable bowel). Anxiolytic: Helps calm overstimulated minds, reduces palpitations, and can help mild anxiety. Mild Hypotensive: May help lower stress-related high blood pressure.
Preparations & dosage
500–1,000 mg, 30 minutes before bed for insomnia or up to 4 times daily for mild pain or stress
Fresh root (1:2, 95% alcohol); dried root (1:5, 60% alcohol); 10 drops to 3 ml (0.6 tsp.) 30 minutes before bed for insomnia or up to 4 times daily for mild pain or stress
4–8 ounces 30 minutes before bed
Safety & precautions
Individual Reactions: Some experience stimulation instead of sedation (particularly those with parasympathetic excess or with low thyroid function). Pregnancy & Hot/Excitable Conditions: Generally not recommended for “hot” individuals who are very nervous or high-strung—scullcap or passionflower may be better. Long-term Use: Large doses over extended periods are not advised, although there is no risk of addiction. Possible Side Effects: Rarely, a floating or “light” feeling may occur, and very high doses can lead to mild hallucinations or insomnia.
Drug & food interactions
Valerian does not appear to affect the metabolism of alprazolam, caffeine, chlorzoxazone, dextromethorphan or midazolam to a clinically relevant extent. Valerian may increase the sleeping time in mice in response to alcohol and barbiturates.
Valerian does not affect the pharmacokinetics of caffeine to a clinically relevant extent. However, the stimulant effects of caffeine may oppose the hypnotic effects of valerian. In a study, 12 non-smoking healthy subjects were given valerian root extract 125 mg three times daily for 28 days with a single 100-mg dose of oral caffeine at the end of supplementation. Valerian root extract caused no significant changes in the metabolism of caffeine.
No interactions found.
Valerian does not affect the pharmacokinetics of chlorzoxazone to a clinically relevant extent. However, additive sedative effects are a possibility. In a study, 12 healthy subjects were given valerian root extract 125 mg three times daily for 28 days with a single 250-mg dose of oral chlorzoxazone at the end of supplementation. Valerian root extract caused no significant changes in the metabolism of chlorzoxazone.
The interaction between valerian and barbiturates is based on experimental evidence only. No interactions found.
The interaction between valerian and alcohol is based on experimental evidence only. No interactions found.
Valerian does not affect the pharmacokinetics of dextromethorphan to a clinically relevant extent. In a crossover study, 12 healthy subjects were given valerian root extract 1 g each night for 14 days, with a single 30-mg dose of dextromethorphan on the morning of day 15. Valerian extract caused no significant changes in the pharmacokinetics of dextromethorphan. The valerian extract used in this study contained 11 mg of valerenic acid per gram.1
Valerian does not affect the pharmacokinetics of alprazolam or midazolam to a clinically relevant extent. However, additive sedative effects are a possibility. In a crossover study, 12 healthy subjects were given valerian root extract 1 g each night for 14 days, with a single 2-mg dose of alprazolam on the morning of day 15. Valerian increased the maximum plasma concentration of alprazolam by 20%, but there were no other statistically significant changes in the pharmacokinetics of alprazolam.1 The valerian extract used in this study contained 11 mg of valerenic acid per gram. In another study, 12 healthy subjects were given valerian root extract 125mg three times daily for 28 days before receiving a single dose of midazolam. Valerian root extract caused no significant changes in the metabolism of midazolam.
Habitat
Native to Europe and northern Asia, valerian flourishes in damp soils, often near rivers. It is grown from seed in spring and harvested in autumn of the second year, when the root and rhizome contain the highest level of active components.
Traditionally used for
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